A REVIEW OF CONOLIDINE ALKALOID FOR CHRONIC PAIN

Most not long ago, it's been identified that conolidine and the above derivatives act over the atypical chemokine receptor 3 (ACKR3. Expressed in very similar places as classical opioid receptors, it binds into a big range of endogenous opioids. Unlike most opioid receptors, this receptor functions like a scavenger and doesn't activate a 2nd messen